BYHWT was originally recorded in the traditional herbal text Yi-Lin-Gai-Cuo (Chinese mean: corrections of errors among physicians) from the Qing Dynasty, published in 1830. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: Funding for this study was provided in part by research grants from the National Science Council (NSC99-2113-M-010-001-MY3, NSC99-2628-B-010-008-MY3) Taiwan Committee on Chinese Medicine and Pharmacy, Department of Health (CCMP99 -RD-024) Taiwan and TCH 94 17 from Taipei City Hospital, Taipei, Taiwan.Ĭompeting interests: The authors have declared that no competing interests exist.īYHWT is one of the most popular formulated traditional Chinese medicine (TCM) prescriptions, with wide use in clinical medication for the treatment and prevention of ischemic cardio-cerebral vascular diseases and stroke-induced disability. Received: Accepted: JPublished: August 29, 2012Ĭopyright: © Shaw et al. These pharmacokinetic results provide a constructive contribution to better understand the absorption mechanism of BYHWT and to support additional clinical evaluation.Ĭitation: Shaw L-H, Lin L-C, Tsai T-H (2012) HPLC–MS/MS Analysis of a Traditional Chinese Medical Formulation of Bu-Yang-Huan-Wu-Tang and Its Pharmacokinetics after Oral Administration to Rats. These phenomenona suggest that these components may have multiple absorption sites, regulation of enterohepatic circulation or the gastric emptying rate, or there is ingredient-ingredient interaction. The other herbal ingredients of formononetin, ononin, calycosin, calycosin-7-O-β-d-glucoside and paeoniflorin appeared together in a single and plateau absorption phase. The pharmacokinetic data demonstrated that astragaloside I, astragaloside II, astragaloside IV and ligustilide presented the phenomenon of double peaks. This developed method was then successfully applied to pharmacokinetic studies of the nine bioactive constituents after oral administration of BYHWT extracts in rats. membranaceus, ligustilide in Radix Angelicae Sinensis and Rhizoma Ligustici Chuanxiong and paeoniflorin in Radix Paeoniae Rubra were identified. Among them, three astragalosides and four isoflavones in A. The overall analytical procedure was rapid and reproducible, which makes it suitable for quantitative analysis of a large number of samples. No significant matrix effects were observed. This method was applied to investigate the pharmacokinetics in conscious and freely moving rats. A specific high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) has been developed and validated for simultaneous quantification of the nine main bioactive components, i.e., astragaloside I, astragaloside II, astragaloside IV, formononetin, ononin, calycosin, calycosin-7-O-β-d-glucoside, ligustilide and paeoniflorin in rat plasma after oral administration of BYHWT extract. Always check with your doctor for risks associated with dietary supplements that could impact your specific health conditions and/or allergies.Bu-yang-huan-wu-tang (BYHWT) is one of the most popular formulated traditional Chinese medicine prescriptions, and is widely for prevention of ischemic cardio-cerebral vascular diseases and stroke-induced disability. *Success Stories and results featured on this web site are atypical. You should not stop taking any medications without first consulting your physician.
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